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Technology # Array version
Species
Organ
Tissue
Physiopathology
Type
Name

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User name	Jean-Claude Sirard
Email	Jean-Claude.Sirard@inserm.fr
Phone / Fax number	+33320877319 / +33320877888
Location	INSERM - Institut Pasteur de Lille (Center for Infection and Immunity of Lille, Team 8, INSERM U1019) - 1 rue du Pr. Calmette - 59019 Lille, France

Scientific description

Adaptive immunity depends on activation of antigen-presenting cells (APC) like dendritic cells. In lymphoid tissues, Toll-like receptors (TLR) that detect microbial signals are instrumental in the direct APC stimulation. Most pathogenic microorganisms target the mucosal barriers and their dissemination into hosts is rapidly circumvented by innate responses regulated by epithelial cells, the main sentinels within mucosa. Here we addressed whether mucosal adaptive immunity depends on direct APC activation by TLR or whether TLR stimulation of non-hematopoietic mucosal cells is required to initiate immunity by transmitting signals to APCs. Our results suggest that, in lung, radioresistant epithelial cells are essential for promoting the TLR5-mediated mucosal and systemic T cell- and antibody-mediated immunity. Thus, we found a swift epithelial production of restricted set of mediators including the chemokine CCL20, known to promote APC recruitment in epithelial tissues. In conclusion, the adaptive immune-enhancing effect of microbial signals on epithelial cells can be harnessed for improving vaccines.

Technical description